Glycerin is safe and effective for psoriasis models –

Dr. Wendy Bollag and lead author Dr. Vivek Choudhary, MCG physiologist and molecular biologist.Credits: Michael Holahan, Augusta University

Patients with psoriasis have reported that glycerin, a cheap, harmless and slightly sweet liquid at the top of many skin lotion ingredient lists, is effective in combating psoriasis, and scientists are now investigating their We have objective evidence to support the report.
They, whether applied topically or ingested in drinking water Glycerin, Or glycerol helps to soothe classic scaly, red, ridged, itchy patches psoriasis Model, Dr. WendyBollag, Cell Physiologist and skin Researchers and her colleagues at the Medical College of Georgia and Charlie Norwood VA Medical Center International journal of molecular science.
Studies also provide more evidence of the different ways glycerin enables healthy maturation. Skin cells Through four stages that provide a smooth and protective skin layer. Psoriasis is an immune problem that usually causes the skin to surface in young adults. cell Instead, it grows rapidly and builds up on inflamed patches.
“There are experimental data showing what these psoriasis patients are reporting,” says Bollag, who first reported nearly 20 years ago. Journal of Investigative Dermatology Its glycerin is a natural alcohol and water attractant known to help improve the appearance of the skin, helping it to mature properly and thereby enhancing its function safely. Was also helpful.
Bollag’s early reports led to many case reports from individuals, and their reports eventually led to newly published studies.
Locally, glycerin is known to have a soothing, emollient effect. But another important part of that magic that helped Dr. Borag portray is the conversion to lipids, or fats, phosphatidylglycerols, which is ultimately our major skin cell type. It regulates the function of keratinocytes and suppresses skin inflammation.
Glycerin enters the skin through pathways such as aquaporin-3, a channel expressed in skin cells. Once inside, MCG scientists have shown that aquaporin 3 injects glycerin into phospholipase-D-2, an enzyme that converts fat in the outer cell membrane. It converts to cellular signals and finally glycerin to phosphatidylglycerol.

In 2018, Bollag and his team reported that topical application of phosphatidylglycerol reduced inflammation and characteristic raised skin patches in a mouse model of psoriasis. This time, they decided to investigate the effects of its widely available precursor glycerin.
A new study used imiquimod, which is known to produce psoriasis-like plaques in humans, to create animal models for problems such as genital warts and some skin cancers. .. Mice drank sweet natural alcohol or scientists applied it topically. In any case, glycerin helped reduce the development of characteristic skin lesions, scientists report, helping to emphasize that glycerin works in multiple ways to improve skin condition. discover.
Externally, glycerin was beneficial in mice lacking phospholipase-D-2 and therefore acted as a emollient. In addition, locally, it appears to be competing with hydrogen peroxide for space within the Aquaporin 3 channel. Hydrogen peroxide is commonly known as a mild preservative, but we also produce it and at low levels it is a cellular signaling molecule. However, at high levels, hydrogen peroxide causes destructive oxidative stress, which can actually cause psoriasis.
Scientists have discovered that local glycerin reduces the level of hydrogen peroxide that enters skin cells. When they applied glycerin and hydrogen peroxide directly to skin cells at the same time, they found that glycerin protects against oxidative stress from hydrogen peroxide.
“Glycerol is basically hydrogen peroxide To get in there and prevent it from invading and increasing oxidative stress, “says Borag. Since oil and water are immiscible, another way glycerin can help is to support the skin’s primary role as a permeable barrier. In extreme cases, when sitting in the tub, the water in the bath does not pass through the skin, so it swells like a balloon, she says.
On the other hand, if mice lacking phospholipase-D-2, which converts cell membrane fats and lipids into signals, ingested glycerin, it simply did not work, says Bollag. Glycerin, paired with enzymes, produces signals essential for skin cell maturation.
Some of their other recent studies have described in more detail how phosphatidylglycerol reduces inflammation.
Bollag wants the next step, including clinical trials with dermatologists and patients, to find a pharmaceutical scientist she thinks would be the best combination of glycerin and phosphatidylglycerol in the same topical cream. It is working.
The addition of phosphatidyl glycerin itself, as well as the glycerin that makes it, is essentially a backup, as there is some evidence that the essential conversion of glycerin to phosphatidylglycerol is not optimal in psoriasis. Bollag’s lab and others have shown reduced levels of aquaporin 3 in psoriasis. This is likely to mean less phosphatidyl diserol, so making more glycerin available is not efficient, but the availability of this lipid, which is essential for normal skin cell proliferation. You can improve your sex.
Will move soon Clinical trials As with glycerin, phosphatidylglycerol has already been used in humans and should be relatively easy. For example, it is an ingredient in some luxury cosmetics, says Bollag.
She keeps this type of two-punch combination away from the early signs of psoriasis, and in more advanced illnesses, she uses existing psoriasis treatments to control the condition of the skin and begins applying glycerin to it. I think I can maintain the condition.
Bollag and her colleagues in 2018 Journal of Investigative Dermatology In a mouse model of psoriasis, phosphatidylglycerol reduced inflammation and caused the characteristic skin lesions of psoriasis.
The exact cause is unknown, but psoriasis is an immune condition that causes patients to develop higher levels of inflammation and have too many skin cells to mature abnormally. Increased inflammation also increases the risk of problems such as heart disease.
Biopharmaceuticals used to treat psoriasis work in a variety of ways to stop this excessive immune response, but in addition to being costly, they can cause patients with problems such as serious infections and cancer. You may be at risk. After working with glycerin for about 20 years, the only side effect she has already seen in clinical and cosmetic use is that the skin can leave a slightly sticky feel.
Our bodies can make glycerol from the carbohydrates, proteins, and fats we eat or already have in our bodies.
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Provided by
Augusta University Medical College of Georgia

Quote: Glycerin is safe and effective in psoriasis models (2021, October 4th). Obtained from https: // on October 4, 2021.
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Glycerin is safe and effective for psoriasis models
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