College football odds, lines, picks, predictions for Week 1, 2021: Computer model backing LSU, Iowa – CBS Sports

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One team will establish itself as a top early-season national title contender when No. 5 Georgia and No. 3 Clemson meet up at 7:30 p.m. ET in Charlotte on Saturday in the marquee game on the Week 1 college football schedule. Caesars Sportsbook lists Clemson as a three-point favorite in the latest Week 1 college football odds, but Georgia is loaded on both sides and is hungry to record a statement win. Top-ranked Alabama, meanwhile, is -18.5 against No. 14 Miami in the Week 1 college football spreads as those traditional powers meet in Atlanta.
Other national title contenders like No. 2 Oklahoma and No. 6 Texas A&M have easier starts to the season. The Sooners are -26.5 as they host Tulane, while the Aggies are -29.5 at home against Kent State. Which Week 1 college football lines have the most value over Labor Day Weekend? Before making any Week 1 college football picks or bets, be sure to see the latest college football predictions from SportsLine’s proven model.
The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,600 for $100 players on its top-rated college football picks against the spread. It also enters Week 1 of the 2021 season on a 57-37 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.
Now, it has turned its attention to the latest Week 1 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.
One of the top college football picks the model is recommending for Week 1: No. 16 LSU (-3.5) covers on the road against UCLA in an 8:30 p.m. ET kickoff at the Rose Bowl on Saturday. A 5-5 campaign in 2020 was a big step back for Ed Orgeron’s squad after winning the national title the year before. But the Tigers are hopeful that offensive coordinator Jake Peetz will help them return to the success they found a couple seasons back.
Max Johnson will start at quarterback and he is surrounded by veterans on offense. UCLA got off to a fast start against Hawaii, but SportsLine’s model is projecting that this talented LSU squad will overwhelm Chip Kelly’s side and pick up a double-digit victory. The Tigers cover in more than 60 percent of simulations, while the under (66) also hits more than 60 percent of the time.
Another one of the college football predictions from the model: No.18 Iowa (-3) covers against No. 17 Indiana in a Big Ten matchup. The Hawkeyes had a top-10 defense in 2020 and they return eight starters on that side of the ball. That unit will have a tough assignment against Indiana quarterback Michael Penix Jr., but SportsLine’s model sees this as a low-scoring matchup.
The teams combine for just 41 points, helping the under (46) hit in well over 60 percent of simulations. Iowa has the edge against the spread, covering more than 50 percent of the time in this 3:30 p.m. ET Saturday matchup in Iowa City. 
The model has also made the call on who wins and covers in every other game on the Week 1 college football schedule, and it’s calling for a national title contender to go down hard. You can only get every pick for every game at SportsLine.
So what college football picks can you make with confidence? And which national title contender goes down hard? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned $3,600 in profit over the past five-plus seasons, and find out.
Here are the college football lines for some of Week 1’s most notable matchups 
Thursday, Sept. 2
Boise State at UCF (-5.5, 68.5)
Ohio State at Minnesota (+14, 65)
Friday, Sept. 3 
North Carolina at Virginia Tech (+5.5, 64)
Michigan State at Northwestern (-3, 45)
Saturday, Sept. 4 
Tulane at Oklahoma (-26.5, 69)
Penn State at Wisconsin (-4.5, 50)
Alabama vs. Miami (+18.5, 62)
Indiana at Iowa (-3, 46)
Louisiana at Texas (-8, 58)
Georgia vs. Clemson (-3, 51.5)
LSU at UCLA (+3.5, 66)
Sunday, Sept. 5 
Notre Dame at Florida State (+7.5, 56)
Monday, Sept. 6
Louisville vs. Ole Miss (-9.5, 75.5)
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